IARC Database of p53 gene mutations in human tumors and cell lines
What you can do:
Search for all TP53 gene mutations identified in human cancers and cell lines that have been reported in the peer-reviewed literature since 1989.
Highlights:
- This database originally consisted of a list of somatic point mutations in the p53 gene of human tumors and cell lines, compiled from the published literature and made available in a standard electronic form.
- The database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989.
- New developments include restructuring of the database, which is now patient-centered, with more detailed annotations on the patient (carcinogen exposure, virus infection, genetic background).
- A new on-line application to retrieve somatic mutation data and analyze mutation patterns is now available.
- The IARC TP53 Mutation Database compiles all TP53 gene mutations identified in human cancers and cell lines that have been reported in the peer-reviewed literature since 1989.
- The following datasets are available:
- . TP53 somatic mutations in sporadic cancers
- . TP53 germline mutation in familial cancers
- . Common TP53 polymorphisms identified in human populations
- . Functional properties of P53 mutant proteins
- . TP53 gene status in human cell-lines
Keywords:
- cancer suppressor gene TP53
- TP53 mutation
- TP53 somatic mutations
- TP53 germline mutation
- p53 mutations
- P53 mutant proteins
- TP53 polymorphisms
- human cancers
- Li-Fraumeni Syndrome
- human neoplasms
- human genetic variations
- human cancer genes
- human disease genes
- glioblastomas
Literature & Tutorials:
This record last updated: 03-31-2006