DOUTfinder x97 identification of distant domain outliers using subsignificant sequence similarity
What you can do:
Detect distantly related protein domains.
Highlights:
- DOUTfinder is a web-based tool facilitating protein domain detection among related protein sequences in the twilight zone of sequence similarity.
- The sequence set required for this analysis can be provided by the user or will be collected using PSI-BLAST if a single sequence is given as an input.
- The obtained sequence family is analyzed for known Pfam and SMART domains, and the thereby identified subsignificant domain similarities are evaluated further.
- Domains with several subthreshold hits in the query set are ranked based on a sum-score function and likely homologous domains are suggested according to established cut-offs.
- By providing a post-filtering procedure for subsignificant domain hits DOUTfinder allows the detection of non-trivial domain relationships and can thereby lead to new insights into the function and evolution of distantly related sequence families.
Keywords:
- protein domain analysis tool
- protein domain similarity analysis tool
- distant protein domain prediction tool
Literature & Tutorials:
This record last updated: 07-24-2006