The Connectivity Map -- Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
What you can do:
Use gene expression profiles to discover functional connections among diseases, genetic perturbation, and drug action.
Highlights:
- The Connectivity Map (also known as cmap) is a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of decisive functional connections between drugs, genes and diseases through the transitory feature of common gene expression changes.
- The resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.
- This web interface is designed to allow biologists, pharmacologists, chemists and clinical scientists to use cmap without the need for any specialist ability in the analysis of gene expression data.
Keywords:
- human gene expression profiles
- gene expression data analysis
- function association analysis
- system biology tool
- human disease
- drug evaluation
- drug design
- pharmacology
- human gene expression data
- human microarray analysis
- bioactive small molecules
- small-molecule perturbagens
- human MCF7 cell lines
- HDAC Inhibitors
- HSP90 inhibitors
- Phenothiazines
- Alzheimer's disease
Literature & Tutorials:
This record last updated: 11-10-2006