PolyPhred -- automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

What you can do:
Compare fluorescence-based sequences across traces obtained from different individuals to identify heterozygous sites for single nucleotide substitutions.
Highlights:
  • PolyPhred identifies potential heterozygotes using the base calls and peak information provided by Phred and the sequence alignments provided by Phrap.
  • Potential heterozygotes identified by PolyPhred are marked for rapid inspection using the Consed tool.
  • PolyPhred's functions are integrated with the use of three other programs: Phred, Phrap, and Consed.
  • The current version 6 also helps automate detection and genotyping of indels (Structural and insertion-deletion variants) from sequence traces.
Keywords:
  • heterozygous sites detection tool
  • single nucleotide substitutions
  • single nucleotide polymorphisms analysis tool
  • SNPs analysis
  • SNP analysis
  • indels detection
  • structural and insertion-deletion variants
  • insertion-deletion polymorphisms detection
  • genetic variation analysis
  • heterozgyosity
  • genotype
  • genotyping
This record last updated: 11-29-2006
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