PROMALS web server for accurate multiple protein sequence alignments

What you can do:
Construct multiple protein sequence alignment
  • Multiple sequence alignments are essential in homology inference, structure modeling, functional prediction and phylogenetic analysis. We developed a web server that constructs multiple protein sequence alignments using PROMALS, a progressive method that improves alignment quality by using additional homologs from PSI-BLAST searches and secondary structure predictions from PSIPRED. PROMALS shows higher alignment accuracy than other advanced methods, such as MUMMALS, ProbCons, MAFFT and SPEM. The PROMALS web server takes FASTA format protein sequences as input. The output includes a colored alignment augmented with information about sequence grouping, predicted secondary structures and positional conservation.
  • Conserved Sequence
  • MSA
  • sequence alignment
  • sequence analysis
  • Homology
This record last updated: 10-27-2007
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