HotSprint -- Computational Hot Spots of Protein Interfaces

What you can do:
Database of computational hot spots in protein interfaces.
Highlights:
  • Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy.
  • HotSprint contains data for 35 776 protein interfaces among 49 512 protein interfaces extracted from the multi-chain structures in Protein Data Bank (PDB) as of February 2006.
  • The conserved residues in interfaces with certain buried accessible solvent area (ASA) and complex ASA thresholds are flagged as computational hot spots.
  • The predicted hot spots are observed to correlate with the experimental hot spots with an accuracy of 76%.
  • Several machine-learning methods (SVM, Decision Trees and Decision Lists) are also applied to predict hot spots, results reveal that our empirical approach performs better than the others.
  • A web interface for the HotSprint database allows users to browse and query the hot spots in protein interfaces.
  • HotSprint provides information for interface residues that are functionally and structurally important as well as the evolutionary history and solvent accessibility of residues in interfaces.
Keywords:
  • Protein Binding
  • Protein Conformation
  • Protein Interaction Mapping
  • Protein Interfaces
  • hot spots
This record last updated: 04-17-2008
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