Greglist -- a database listing potential G-quadruplex regulated genes
What you can do:
Find genes whose promoter regions have G-quadruplex motifs.
Highlights:
- The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression; the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity.
- Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters.
- To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes.
- Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens.
- Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK.
- Not only protein coding genes, 126 human microRNAs also contain promoter GQMs.
Keywords:
- Chickens
- G-Quadruplexes
- GQM
- Gene Expression Regulation
- Humans
- Mice
- MicroRNAs
- Promoter Regions
- Rats
Literature & Tutorials:
PubMed Link of a related article: Greglist: a database listing potential G-quadruplex regulated genes
This record last updated: 04-30-2008