eggNOG -- evolutionary genealogy of genes: Non-supervised Orthologous Groups

URL:

http://eggnog.embl.de

What you can do:

Discover orthologous groups of genes.

Highlights:

Contains orthologous groups constructed from Smith-Waterman alignments through identification of reciprocal best matches and triangular linkage clustering.
Applying this procedure to 630 complete genomes (529 bacteria, 46 archaea and 55 eukaryotes), which is a 2-fold increase relative to the previous version, yielded 224,847 OGs, including 9724 extended versions of the original COG and KOG.
OGs were computed for different levels of the tree of life; in addition to the species groups included in our first release (i.e. fungi, metazoa, insects, vertebrates and mammals), we have now constructed OGs for archaea, fishes, rodents and primates.
The non-supervised orthologous groups (NOGs) were automatically annotated with functional descriptions, protein domains, and functional categories as defined initially for the COG/KOG database.
In-depth analysis is facilitated by precomputed high-quality multiple sequence alignments and maximum-likelihood trees for each of the available OGs.
eggNOG covers 2,242 035 proteins (built from 2,590,259 proteins) and provides a broad functional description for at least 1,966,709 (88%) of them.

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Literature & Tutorials:

This record last updated: 01-25-2010