ZiFiT -- Zinc Finger Targeter

What you can do:
An engineered zinc finger/target site design tool.
  • Zinc Finger Targeter (ZiFiT) is a simple and intuitive web-based tool that facilitates the design of zinc finger proteins (ZFPs) that can bind to specific DNA sequences.
  • The current version of ZiFiT is based on a widely employed method of ZFP design, the 'modular assembly' approach, in which pre-existing individual zinc fingers are linked together to recognize desired target DNA sequences.
  • Several research groups have described experimentally characterized zinc finger modules that bind many of the 64 possible DNA triplets.
  • ZiFiT leverages the combined capabilities of three of the largest and best characterized module archives by enabling users to select fingers from any of these sets.
  • ZiFiT searches a query DNA sequence for target sites for which a ZFP can be designed using modules available in one or more of the three archives.
  • In addition, ZiFiT output facilitates identification of specific zinc finger modules that are publicly available from the Zinc Finger Consortium.
  • Binding Sites
  • DNA-Binding Proteins
  • Protein Conformation
  • Protein Engineering
  • Secondary Protein Structure
  • Tertiary Protein Structure
  • Zinc Fingers
This record last updated: 06-02-2008
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