SH3-Hunter -- discovery of SH3 domain interaction sites in proteins
What you can do:
Identify putative SH3 domain interaction sites on protein sequences.
Highlights:
- Given an input query consisting of one or more protein sequences, the server identifies peptides containing poly-proline binding motifs and associates them to a list of SH3 domains, in order to compose peptide-domain pairs.
- The server can accept a list of peptides and allows users to upload an input file in a proper format.
- An accurate selection of SH3 domains is available and users can also submit their own SH3 domain sequence.
- SH3-Hunter evaluates which peptide-domain pair represents a possible interaction pair and produces as output a list of significant interaction sites for each query protein.
- Each proposed interaction site is associated to a propensity score and sensitivity and precision levels for the prediction.
- The server prediction capability is based on a neural network model integrating high-throughput pep-spot data with structural information extracted from known SH3-peptide complexes.
Keywords:
- Amino Acid Motifs
- Binding Sites
- src Homology Domains
- SH3
- domain interaction sites
- poly-proline binding motifs
- peptide-domain pairs
Literature & Tutorials:
This record last updated: 06-03-2008