MinActionPath -- maximum likelihood trajectory for large-scale structural transitions in a coarse-grained locally harmonic energy landscape
What you can do:
Generate the most probable trajectory between two states.
Highlights:
- Here we describe a web tool that implements a new method to calculate the most probable trajectory that is exact for harmonic potentials; as an illustration of the method, the classical Calpha-based Elastic Network Model (ENM) is used both for the initial and the final states but other variants of the ENM are also possible.
- The Langevin equation under this potential is solved analytically using the Onsager and Machlup action minimization formalism on each side of the transition, thus replacing the original non-linear problem by a pair of linear differential equations joined by a non-linear boundary matching condition.
- The crossover between the two multidimensional energy curves around each state is found numerically using an iterative approach, producing the most probable trajectory and fully characterizing the transition state and its energy.
Keywords:
- Amino Acid Sequence
- Energy Transfer
- Molecular Sequence Data
- Protein Conformation
- Protein Structure
- Thermodynamics
- trajectory
- harmonic potentials
Literature & Tutorials:
This record last updated: 06-03-2008