The Gibbs Centroid Sampler

What you can do:
Locate conserved elements in biopolymer sequences.
Highlights:
  • The Gibbs Centroid Sampler reports a centroid alignment, i.e. an alignment that has the minimum total distance to the set of samples chosen from the a posteriori probability distribution of transcription factor binding-site alignments.
  • In so doing, it garners information from the full ensemble of solutions, rather than only the single most probable point that is the target of many motif-finding algorithms, including its predecessor, the Gibbs Recursive Sampler.
  • Centroid estimators have been shown to yield substantial improvements, in both sensitivity and positive predictive values, to the prediction of RNA secondary structure and motif finding.
Keywords:
  • Repetitive Sequences,
  • Sequence Analysis
  • Transcription Factors
  • Transcription Initiation Site
  • centroid
  • conserved elements
  • motif
Literature & Tutorials:
This record last updated: 06-04-2008
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