firestar -- prediction of functionally important residues using structural templates and alignment reliability

What you can do:
An expert system for predicting ligand-binding residues in protein structures.
  • The server provides a method for extrapolating from the large inventory of functionally important residues organized in the FireDB database and adds information about the local conservation of potential-binding residues.
  • The interface allows users to make queries by protein sequence or structure.
  • The user can access pairwise and multiple alignments with structures that have relevant functionally important binding sites.
  • The results are presented in a series of easy to read displays that allow users to compare binding residue conservation across homologous proteins.
  • The binding site residues can also be viewed with molecular visualization tools.
  • One feature of firestar is that it can be used to evaluate the biological relevance of small molecule ligands present in PDB structures.
  • With the server it is easy to discern whether small molecule binding is conserved in homologous structures.
  • Binding Sites
  • Catalytic Domain
  • Ligands
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Homology
  • ligand-binding residues
  • protein structure
This record last updated: 06-05-2008
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