firestar -- prediction of functionally important residues using structural templates and alignment reliability

URL:
http://firedb.bioinfo.cnio.es/Php/FireStar.php
What you can do:
An expert system for predicting ligand-binding residues in protein structures.
Highlights:
  • The server provides a method for extrapolating from the large inventory of functionally important residues organized in the FireDB database and adds information about the local conservation of potential-binding residues.
  • The interface allows users to make queries by protein sequence or structure.
  • The user can access pairwise and multiple alignments with structures that have relevant functionally important binding sites.
  • The results are presented in a series of easy to read displays that allow users to compare binding residue conservation across homologous proteins.
  • The binding site residues can also be viewed with molecular visualization tools.
  • One feature of firestar is that it can be used to evaluate the biological relevance of small molecule ligands present in PDB structures.
  • With the server it is easy to discern whether small molecule binding is conserved in homologous structures.
Keywords:
  • Binding Sites
  • Catalytic Domain
  • Ligands
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Homology
  • ligand-binding residues
  • protein structure
Literature & Tutorials:
PubMed Link: firestar--prediction of functionally important residues using structural templates and alignment reliability
This record last updated: 06-05-2008
Report a missing or misdirected URL.

The Health Sciences Library System supports the Health Sciences at the University of Pittsburgh.

© 1996 - 2023 Health Sciences Library System, University of Pittsburgh. All rights reserved.