DAhunter -- Domain Architecture hunter
What you can do:
A retrieval tool for conserved protein domain architecture.
Highlights:
- DAhunter is a web-based server that identifies homologous proteins by comparing domain architectures, the organization of protein domains.
- A major obstacle in comparison of domain architecture is the existence of 'promiscuous' domains, which carry out auxiliary functions and appear in many unrelated proteins.
- To distinguish these promiscuous domains from protein domains, we assigned a weight score to each domain extracted from RefSeq proteins, based on its abundance and versatility.
- A domain's score represents its importance in the 'protein world' and is used in the comparison of domain architectures.
- In scoring domains, DAhunter also considers domain combinations as well as single domains.
- To measure the similarity of two domain architectures, we developed several methods that are based on algorithms used in information retrieval (the cosine similarity, the Goodman-Kruskal gamma function, and domain duplication index) and then combined these into a similarity score.
- Compared with other domain architecture algorithms, DAhunter is better at identifying homology.
- Also available at http://localodom.kobic.re.kr/dahunter/index.htm.
Keywords:
- protein domain architecture
- domain architecture
- conserved domain
- protein domains
- promiscuous domains
- protein homology
Literature & Tutorials:
This record last updated: 07-18-2008