MKT -- The McDonald and Kreitman test

URL:
http://mkt.uab.es
What you can do:
Detect the signature of natural selection at the molecular level.
Highlights:
  • This novel website allows performing MKTs not only for synonymous and nonsynonymous changes, as the test was initially described, but also for other classes of regions and/or several loci.
  • The website has three different interfaces: (i) the standard MKT, where users can analyze several types of sites in a coding region, (ii) the advanced MKT, where users can compare two closely linked regions in the genome that can be either coding or noncoding, and (iii) the multi-locus MKT, where users can analyze many separate loci in a single multi-locus test.
  • The website has already been used to show that selection efficiency is positively correlated with effective population size in the Drosophila genus and it has been applied to include estimates of selection in DPDB.
Keywords:
  • adaptive evolution
  • natural selection
  • MKT
  • McDonald and Kreitman
  • synonymous changes
  • nonsynonymous changes
Literature & Tutorials:
PubMed Link: Standard and generalized McDonald-Kreitman test: a website to detect selection by comparing different classes of DNA sites
This record last updated: 07-22-2008
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