webPIPSA -- Protein Interaction Property Similarity Analysis

What you can do:
A web server for the comparison of protein interaction properties.
Highlights:
  • Protein molecular interaction fields are key determinants of protein functionality.
  • PIPSA (Protein Interaction Property Similarity Analysis) is a procedure to compare and analyze protein molecular interaction fields, such as the electrostatic potential.
  • PIPSA may assist in protein functional assignment, classification of proteins, the comparison of binding properties and the estimation of enzyme kinetic parameters.
  • webPIPSA is a web server that enables the use of PIPSA to compare and analyze protein electrostatic potentials.
  • While PIPSA can be run with downloadable software (see http://projects.eml.org/mcm/software/pipsa), webPIPSA extends and simplifies a PIPSA run. This allows non-expert users to perform PIPSA for their protein datasets.
  • With input protein coordinates, the superposition of protein structures, as well as the computation and analysis of electrostatic potentials, is automated.
  • The results are provided as electrostatic similarity matrices from an all-pairwise comparison of the proteins which can be subjected to clustering and visualized as epograms (tree-like diagrams showing electrostatic potential differences) or heat maps.
Keywords:
  • protein molecular interaction fields
  • protein interaction properties
  • binding properties
  • enzyme kinetic parameters
  • protein electrostatic interaction properties
This record last updated: 07-24-2008
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