Exalign -- a new method for comparative analysis of exon-intron gene structures

What you can do:
An algorithm designed to retrieve, compare and search for the exon-intron structure of existing gene annotations.
Highlights:
  • The evolution of genes is usually studied and reconstructed at the sequence level, that is, by comparing and aligning their genomic, transcript or protein sequences.
  • However, including the exon-intron structure of genes in the analysis can provide further and useful information, for example to draw reliable phylogenetic relationships left unsolved by traditional sequence-based evolutionary studies, or to shed further light on patterns of intron gain and loss.
Keywords:
  • exon-intron
  • gene structure
  • phylogenetic relationships
This record last updated: 04-18-2014

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