TOPDOM -- Conservatively Located Domains and Motifs in Transmembrane Proteins

What you can do:
Database of domains and motifs with conservative location in transmembrane proteins.
  • The TOPDOM database is a collection of domains and sequence motifs located consistently on the same side of the membrane in alpha-helical transmembrane proteins.
  • The database was created by scanning well-annotated transmembrane protein sequences in the UniProt database by specific domain or motif detecting algorithms.
  • The identified domains or motifs were added to the database if they were uniformly annotated on the same side of the membrane of the various proteins in the UniProt database.
  • The information about the location of the collected domains and motifs can be incorporated into constrained topology prediction algorithms, like HMMTOP, increasing the prediction accuracy.
  • Protein Structure
  • protein sequence analysis
  • Membrane Proteins
  • Amino Acid Motifs
  • protein motif
  • transmembrane protein
  • protein domain
This record last updated: 09-03-2008
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