MotifMap -- a human genome-wide map of candidate regulatory motif sites

URL:

http://motifmap.ics.uci.edu

What you can do:

Explore a comprehensive map of regulatory elements in the human genome.

Highlights:

We developed a procedure for identifying regulatory sites, with high levels of conservation across different species, using a new scoring scheme, the Bayesian branch length score (BBLS).
Using BBLS, we predict 1.5 million regulatory sites, corresponding to 380 known regulatory motifs, with an estimated false discovery rate (FDR) of less than 50%.
We demonstrate that the method is particularly effective for 155 motifs, for which 121,056 sites can be mapped with an estimated FDR of less than 10%.
Over 28K SNPs are located in regions overlapping the 1.5 million predicted motif sites, suggesting potential functional implications for these SNPs.
We have deposited these elements in a database and created a user-friendly Web server for the retrieval, analysis, and visualization of these elements.
The initial map provides a systematic view of gene regulation in the genome, which will be refined as additional motifs become available.

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Literature & Tutorials:

This record last updated: 11-24-2008