PhosphoPOINT -- a comprehensive human kinase interactome and phospho-protein database

What you can do:
Uncover novel substrates for specific kinases.
Highlights:
  • PhosphoPOINT is a collection of 4195 phospho-proteins with a total of 15 738 phosphorylation sites.
  • It annotates the interactions among kinases, with their down-stream substrates and with interacting (phospho)-proteins to modulate the kinase-substrate pairs.
  • PhosphoPOINT implements various gene expression profiles and Gene Ontology cellular component information to evaluate each kinase and their interacting (phospho)-proteins/substrates.
  • Integration of cSNPs that cause amino acids change with the proteins with the phosphoprotein dataset reveals that 64 phosphorylation sites result in a disease phenotypes when changed; the linked phenotypes include schizophrenia and hypertension.
  • PhosphoPOINT also provides a search function for all phospho-peptides using about 300 known kinase/phosphatase substrate/binding motifs.
  • Altogether, PhosphoPOINT provides robust annotation for kinases, their downstream substrates and their interaction (phospho)-proteins and this should accelerate the functional characterization of kinomemediated signaling.
Keywords:
  • Phosphoproteins
  • Phosphorylation
  • Phosphotransferases
  • Protein Binding
  • Protein Interaction Mapping
  • Kinase
  • phospho-protein
This record last updated: 11-25-2008
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