MoKCA -- mutations of kinases in cancer database
What you can do:
Information on the phenotypic consequences of mutations in protein kinases implicated in cancer.
Highlights:
- The MoKCa database has been developed to structurally and functionally annotate, and where possible predict, the phenotypic consequences of mutations in protein kinases implicated in cancer.
- Somatic mutation data from tumours and tumour cell lines have been mapped onto the crystal structures of the affected protein domains.
- Positions of the mutated amino-acids are highlighted on a sequence-based domain pictogram, as well as a 3D-image of the protein structure, and in a molecular graphics package, integrated for interactive viewing.
- The data associated with each mutation is presented in the Web interface, along with expert annotation of the detailed molecular functional implications of the mutation.
- Proteins are linked to functional annotation resources and are annotated with structural and functional features such as domains and phosphorylation sites.
- MoKCa aims to provide assessments available from multiple sources and algorithms for each potential cancer-associated mutation.
Keywords:
- tumor
- kinase
- cancer
- protein
- mutation
Literature & Tutorials:
PubMed Link: MoKCa database--mutations of kinases in cancer
This record last updated: 01-14-2009