INTREPID -- INformation-theoretic TREe traversal for Protein functional site IDentification
What you can do:
Use for protein functional site identification.
Highlights:
- INTREPID is web server for predicting functionally important residues in proteins.
- It has been shown to boost the recall and precision of catalytic residue prediction over other sequence-based methods and can be used to identify other types of functional residues.
- The web server takes an input protein sequence, gathers homologs, constructs a multiple sequence alignment and phylogenetic tree and finally runs the INTREPID method to assign a score to each position.
- Residues predicted to be functionally important are displayed on homologous 3D structures (where available), highlighting spatial patterns of conservation at various significance thresholds.
Keywords:
- protein functional site prediction
- multiple sequence alignment
Literature & Tutorials:
This record last updated: 08-20-2009