INTREPID -- INformation-theoretic TREe traversal for Protein functional site IDentification

What you can do:
Use for protein functional site identification.
  • INTREPID is web server for predicting functionally important residues in proteins.
  • It has been shown to boost the recall and precision of catalytic residue prediction over other sequence-based methods and can be used to identify other types of functional residues.
  • The web server takes an input protein sequence, gathers homologs, constructs a multiple sequence alignment and phylogenetic tree and finally runs the INTREPID method to assign a score to each position.
  • Residues predicted to be functionally important are displayed on homologous 3D structures (where available), highlighting spatial patterns of conservation at various significance thresholds.
  • protein functional site prediction
  • multiple sequence alignment
This record last updated: 08-20-2009
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