ToppGene Suite -- Transcriptome, ontology, phenotype, proteome, and pharmacome annotation web server

URL:
http://toppgene.cchmc.org/
What you can do:
Find information about gene sets and networks.
Highlights:
  • ToppGene Suite is a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome.
  • Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations.
  • The similarity scores from individual features are combined into an overall score using statistical meta-analysis.
  • A P-value of each annotation of a test gene is derived by random sampling of the whole genome.
  • The protein-protein interaction network (PPIN)-based disease candidate gene prioritization uses social and Web networks analysis algorithms (extended versions of the PageRank and HITS algorithms, and the K-Step Markov method).
Keywords:
  • ToppGene
  • protein-protein interaction
  • gene network
  • gene set
  • gene functional annotation
  • gene ontology
  • ToppFun
  • ToppNet
  • ToppGenet
Literature & Tutorials:
PubMed Link: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
This record last updated: 09-25-2009
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