ToppNet -- Relative importance of candidate genes in protein-protein interaction network, from ToppGene Suite
What you can do:
Prioritize or rank candidate genes based on topological features in protein-protein interaction network.
Highlights:
- ToppNet is part of ToppGene Suite, a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome.
- ToppNet focuses on candidate gene ranking by relative importance within a network.
- Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations.
- The similarity scores from individual features are combined into an overall score using statistical meta-analysis.
- A P-value of each annotation of a test gene is derived by random sampling of the whole genome.
- The protein-protein interaction network (PPIN)-based disease candidate gene prioritization uses social and Web networks analysis algorithms (extended versions of the PageRank and HITS algorithms, and the K-Step Markov method).
Keywords:
- ToppGene
- protein-protein interaction
- gene network
- gene set
- gene functional annotation
- gene ontology
Literature & Tutorials:
This record last updated: 09-25-2009