Isobase -- IsoRank PPI Network Alignment Based Ortholog Database

URL:

http://groups.csail.mit.edu/cb/mna/isobase/

What you can do:

Find information about functionally related orthologs.

Highlights:

IsoBase is a database identifying functionally related proteins across five major eukaryotic model organisms: Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus and Homo Sapiens.
It performs ortholog detection by the integration of sequence data and protein-protein interaction (PPI) networks to help in identifying true functionally related proteins.
The groupings were computed using the IsoRankN algorithm that uses spectral methods to combine sequence and PPI data and produce clusters of functionally related proteins.
These clusters compare favorably with those from existing approaches: proteins within an IsoBase cluster are more likely to share similar Gene Ontology (GO) annotation.
A total of 48,120 proteins were clustered into 12,693 functionally related groups.
The IsoBase database may be browsed for functionally related proteins across two or more species and may also be queried by accession numbers, species-specific identifiers, gene name or keyword.

Keywords:

Literature & Tutorials:

This record last updated: 06-14-2011