RegPhos -- REGulatory Network in Protein PHOSphorylation

What you can do:
Find information about the protein kinase-substrate phosphorylation network in humans.
Highlights:
  • RegPhos is a knowledgebase developed to integrate experimentally verified protein phosphorylation data and protein-protein interaction data for constructing the protein kinase-substrate phosphorylation networks in human.
  • A total of 21,110 experimental verified phosphorylation sites within 5092 human proteins are collected.
  • Only 4138 phosphorylation sites (∼20%) have the annotation of catalytic kinases from public domain.
  • In order to fully investigate how protein kinases regulate the intracellular processes, a published kinase-specific phosphorylation site prediction tool, named KinasePhos is incorporated for assigning the potential kinase.
  • The web-based system, RegPhos, can let users input a group of human proteins; consequently, the phosphorylation network associated with the protein subcellular localization can be explored.
  • Time-coursed microarray expression data is subsequently used to represent the degree of similarity in the expression profiles of network members.
Keywords:
  • protein kinase
  • kinase-substrate phosphorylation
  • phosphorylation site
  • protein-protein interaction
  • PPI
Literature & Tutorials:
This record last updated: 06-14-2011
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