FoldMiner and LOCK 2 -- Protein structure comparison and motif discovery on the web
What you can do:
Perform protein structure alignment and unsupervised motif discovery.
Highlights:
- It improves both the motif definition and the sensitivity of a structural similarity search by combining the search and motif discovery methods and using information from each process to enhance the other.
- A query structure is aligned to all structures in one of several databases of single domain targets in order to identify its structural neighbors and to discover a motif that is the basis for the similarity among the query and statistically significant targets. This process is fully automated, but options for manual refinement of the results are available as well.
- The server uses the Chime plugin and customized controls to allow for visualization of the motif and of structural superpositions.
- An interface to the LOCK 2 algorithm is available for rapid alignments of a query structure to smaller numbers of user-specified targets.
Keywords:
- protein structures
- protein motif prediction
- protein structure alignments
- protein domains
Literature & Tutorials:
PubMed Link: FoldMiner and LOCK 2
This record last updated: 05-11-2005