CaspR -- A web server for automated molecular replacement using homology modeling
What you can do:
Optimize molecular replacement procedure using a combination of well-established stand-alone software tools.
Highlights:
- The protocol of model building and screening begins with the generation of multiple structurex96sequence alignments produced with T-COFFEE, followed by homology model building using MODELLER, molecular replacement with AMoRe and model refinement based on CNS.
- As a result, CaspR provides a progress report in the form of hierarchically organized summary sheets that describe the different stages of the computation with an increasing level of detail.
- For the 10 highest-scoring potential solutions, pre-refined structures are made available for download in PDB format. S
- Such a strategy significantly increases the fraction of protein structures which may be solved by MR. Moreover, even in situations where standard MR yields a solution, pre-refined homology models produced by CaspR significantly reduce the time-consuming refinement process.
Keywords:
- protein structures
- Molecular replacement
- X-ray crystallography
- protein modeling
- protein homology
- structure to sequence alignments
- protein structure alignment
Literature & Tutorials:
PubMed Link: CaspR
This record last updated: 05-11-2005