Fragnostic -- walking through protein structure space
What you can do:
Discover structural and functional relationships between proteins which are distantly related or seemingly unrelated.
Highlights:
- This Web tool implements a novel and useful view of protein structure space.
- The authors mined a non-redundant subset of the PDB for common fragments shared between proteins inhabiting different SCOP folds, and subsequently formulated an inter-fold similarity measure based on fragment sharing.
- Fold space is described as a graph whose nodes are folds between which the edges are drawn depending on the extent of fragment sharing.
- In this fashion, Fragnostic helps discover meaningful relationships between proteins belonging to different folds, based on sharing similar fragments in the proteins comprising those folds.
- Distant fold similarity information is supplemented by annotations taken from Gene Ontology, SCOP and CATH.
Keywords:
- protein structure analysis tool
- protein fold analysis tool
- protein folds
- protein folding
- protein homology
- protein structure space
Literature & Tutorials:
This record last updated: 11-08-2005