I-Mutant 2.0 -- predicting stability changes upon mutation from the protein sequence or structure
What you can do:
Predict protein stability changes upon single point mutations in protein sequence.
Highlights:
- I-Mutant2.0 is a support vector machine (SVM)-based tool for the automatic prediction of protein stability changes upon single point mutations.
- The predictions are performed starting either from the protein structure or, more importantly, from the protein sequence.
- I-Mutant2.0 can be used both as a classifier for predicting the sign of the protein stability change upon mutation and as a regression estimator for predicting the related DeltaDeltaG values.
- The Web interface allows the selection of a predictive mode that depends on the availability of the protein structure and/or sequence.
- I-Mutant2.0 is a unique and valuable helper for protein design, even when the protein structure is not yet known with atomic resolution.
Keywords:
- protein stability
- protein stability prediction tool
- protein engineering tool
- protein design tool
- protein modeling
- protein single point mutations
- protein tertiary structures
Literature & Tutorials:
This record last updated: 07-24-2006