GRSDB2 -- a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences

URL:

http://bioinformatics.ramapo.edu/grsdb/

What you can do:

Search for information on composition and distribution of putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the alternatively processed (alternatively spliced or alternatively polyadenylated) mammalian pre-mRNA sequences.

Highlights:

GRSDB2 is a second-generation database containing information on the composition and distribution of putative Quadruplex-forming G-Rich Sequences (QGRS) mapped in approximately 29 000 eukaryotic pre-mRNA sequences, many of which are alternatively processed.
The data stored in the GRSDB2 is based on computational analysis of NCBI Entrez Gene entries with the help of an improved version of the QGRS Mapper program.
The database allows complex queries with a wide variety of parameters, including Gene Ontology terms.
The data is displayed in a variety of formats with several additional computational capabilities.
We have also developed a new database, GRS_UTRdb, containing information on the composition and distribution patterns of putative QGRS in the 5'- and 3'-UTRs of eukaryotic mRNA sequences.
The goal of these experiments has been to build freely accessible resources for exploring the role of G-quadruplex structure in regulation of gene expression at post-transcriptional level.

Keywords:

G-quadruplex structures
G-quartets
G-rich sequences
mammalian pre-mRNAs
G-rich motifs
RNA processing sites
alternative RNA processing
RNA structures

Literature & Tutorials:

PubMed Link: GRSDB -- a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences
2008 Update: GRSDB2 and GRS_UTRdb: databases of quadruplex forming G-rich sequences in pre-mRNAs and mRNAs

This record last updated: 05-02-2008

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