CUPSAT -- prediction of protein stability upon point mutations
What you can do:
Analyze and predict protein stability changes upon point mutations.
Highlights:
- CUPSAT is a web tool to analyze and predict protein stability changes upon point mutations.
- It uses structural environment specific atom potentials and torsion angle potentials to predict the difference in free energy of unfolding between wild-type and mutant proteins.
- It requires the protein structure in Protein Data Bank format and the location of the residue to be mutated.
- The output consists information about mutation site, its structural features (solvent accessibility, secondary structure and torsion angles), and comprehensive information about changes in protein stability for 19 possible substitutions of a specific amino acid mutation.
- Additionally, it also analyses the ability of the mutated amino acids to adapt the observed torsion angles.
Keywords:
- protein stability analysis tool
- protein point mutations
- mutant protein stability prediction tool
- protein design tool
Literature & Tutorials:
This record last updated: 04-18-2014