RF-DYMHC -- Detecting the yeast meiotic recombination hotspots and coldspots by random forest model using gapped dinucleotide composition features
What you can do:
Detect recombination hot/cold spots from yeast genome.
Highlights:
- In the yeast, meiotic recombination is initiated by double-strand DNA breaks (DSBs) which occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots).
- Although observations concerning individual hot/cold spots have given clues as to the mechanism of recombination initiation, the prediction of hot/cold spots from DNA sequence information is a challenging task.
- This resource introduces a random forest (RF) prediction model to detect recombination hot/cold spots from yeast genome.
- The prediction model is implemented as a web server (RF-DYMHC) and is freely available.
- Given a yeast genome and prediction parameters (RI-value and non-overlapping window scan size), the program reports the predicted hot/cold spots and marks them in color.
Keywords:
- Algorithms
- Artificial Intelligence
- Chromosome Mapping/*methods
- Codon/*genetics
- Computational Biology/*methods
- Genome, Fungal/genetics
- Meiosis/*genetics
- Nucleotides/*genetics
- Pattern Recognition, Automated/methods
- Recombination, Genetic/genetics
- Saccharomyces cerevisiae/*cytology/*genetics
- Sequence Analysis, DNA/*methods
Literature & Tutorials:
This record last updated: 10-10-2007