LigASite -- LIGand Attachment SITE
What you can do:
Database of biologically relevant binding sites in proteins with known apo-structures
Highlights:
- A gold-standard dataset of binding sites in 550 proteins of known structures, LigASite consists exclusively of biologically relevant binding sites in proteins for which at least one apo- and one holo-structure are available.
- In defining the binding sites for each protein, information from all holo-structures is combined, considering in each case the quaternary structure defined by the PQS server.
- LigASite is built using simple criteria and is automatically updated as new structures become available in the PDB, thereby guaranteeing optimal data coverage over time.
- Both a redundant and a culled non-redundant version of the dataset is available.
- The website interface allows users to search the dataset by PDB identifiers, ligand identifiers, protein names or sequence, and to look for structural matches as defined by the CATH homologous superfamilies.
- The datasets can be downloaded from the website as Schema-validated XML files or comma-separated flat files.
Keywords:
- Apoproteins
- Binding Sites
- Protein statistics
- Ligands
- Protein Conformation
- apo-structures
- PDB
Literature & Tutorials:
This record last updated: 04-17-2008