BioHealthBase -- bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens
What you can do:
Provides a comprehensive genomic and proteomic data repository for five pathogenic organism groups that pose a threat to public health.
Highlights:
- The BioHealthBase Bioinformatics Resource Center is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens-Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin.
- The BioHealthBase serves as an extensive integrated repository of data imported from public databases, data derived from various computational algorithms and information curated from the scientific literature.
- The goal of the BioHealthBase is to facilitate the development of therapeutics, diagnostics and vaccines by integrating all available data in the context of host-pathogen interactions, thus allowing researchers to understand the root causes of virulence and pathogenicity.
- Genome and protein annotations can be viewed either as formatted text or graphically through a genome browser.
- 3D visualization capabilities allow researchers to view proteins with key structural and functional features highlighted.
- Influenza virus host-pathogen interactions at the molecular/cellular and systemic levels are represented.
- Host immune response to influenza infection is conveyed through the display of experimentally determined antibody and T-cell epitopes curated from the scientific literature or as derived from computational predictions.
- At the molecular/cellular level, the BioHealthBase BRC has developed biological pathway representations relevant to influenza virus host-pathogen interaction in collaboration with the Reactome database (http://www.reactome.org).
Keywords:
- Duck virology
- Viral Genes
- Host-Pathogen Interactions
- Humans
- Influenza
- Influenza A Virus
- H5N1
- pathogenicity
- Orthomyxoviridae
- Protein Conformation
- Sequence Alignment
- Protein Sequence Analysis
- Viral Proteins
- Virulence
- public health threat
Literature & Tutorials:
This record last updated: 04-17-2008