pKNOT -- the protein KNOT web server
What you can do:
Locate info on knotted proteins.
Highlights:
- Studies show that the knot regions contribute to both ligand binding and enzyme activity in proteins such as the chromophore-binding domain of phytochrome, ketol-acid reductoisomerase or SpoU methyltransferase.
- However, there are still many misidentified knots published in the literature due to the absence of a convenient web tool available to the general biologists.
- Here, we present the first web server to detect the knots in proteins as well as provide information on knotted proteins in PDB-the protein KNOT (pKNOT) web server.
- In pKNOT, users can either input PDB ID or upload protein coordinates in the PDB format.
- The pKNOT web server will detect the knots in the protein using the Taylor's smoothing algorithm.
- All the detected knots can be visually inspected using a Java-based 3D graphics viewer.
Keywords:
- Phytochrome
- Protein Conformation
- Protein Folding
- knot
- knotted proteins
- protein knots
Literature & Tutorials:
PubMed Link: pKNOT: the protein KNOT web server
This record last updated: 06-03-2008