TFAM -- an online tRNA function classifier
What you can do:
Classify the function of tRNAs.
Highlights:
- Unlike tRNA gene-finders, TFAM uses information from the total sequences of tRNAs and not just their anticodons to predict their function.
- Therefore TFAM has an advantage in predicting
- initiator tRNAs, the amino acid charging identity of nonstandard tRNAs such as suppressors, and the former identity of pseudo-tRNAs.
- In addition, TFAM predictions are robust to sequencing errors and useful for the statistical analysis of tRNA sequence, function and evolution.
- Earlier versions of TFAM required a complicated installation and running procedure, and only bacterial tRNA identity models were provided.
- New TFAM models are available including a proteobacterial model for the bacterial lysylated isoleucine tRNAs, making it now possible for TFAM to correctly classify all tRNA genes for some bacterial taxa. First-draft eukaryotic and archaeal models are also provided making initiator tRNA prediction easily accessible genes to any researcher or genome sequencing effort.
Keywords:
- Gene Transfer
- Phylogeny
- transfer RNA
- tRNA
- variation
- initiator tRNAs
- pseudo-tRNAs
Literature & Tutorials:
PubMed Link: TFAM 1.0: an online tRNA function classifier
This record last updated: 04-21-2014