g:Profiler -- a web-based toolset for functional profiling of gene lists from large-scale experiments
What you can do:
A public web server for characterising and manipulating gene lists resulting from mining high-throughput genomic data.
Highlights:
- g:Profiler has a simple, user-friendly web interface with powerful visualisation for capturing Gene Ontology (GO), pathway, or transcription factor binding site enrichments down to individual gene levels.
- Besides standard multiple testing corrections, a new improved method for estimating the true effect of multiple testing over complex structures like GO has been introduced.
- Interpreting ranked gene lists is supported from the same interface with very efficient algorithms.
- Such ordered lists may arise when studying the most significantly affected genes from high-throughput data or genes co-expressed with the query gene.
- Other important aspects of practical data analysis are supported by modules tightly integrated with g:Profiler.
- These are: g:Convert for converting between different database identifiers; g:Orth for finding orthologous genes from other species; and g:Sorter for searching a large body of public gene expression data for co-expression.
- g:Profiler supports 31 different species, and underlying data is updated regularly from sources like the Ensembl database.
- Bioinformatics communities wishing to integrate with g:Profiler can use alternative simple textual outputs.
Keywords:
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- functional profiling
- gene lists
Literature & Tutorials:
This record last updated: 06-04-2008