Superimpose -- a 3D structural superposition server
What you can do:
Performs structural similarity searches with a preference towards 3D structure-based methods.
Highlights:
- Similarities can be detected between small molecules (e.g. drugs), parts of large structures (e.g. binding sites of proteins) and entire proteins.
- For this purpose, a number of algorithms were implemented and various databases are provided.
- Superimposxe9 assists the user regarding the selection of a suitable combination of algorithm and database.
- After the computation on our server infrastructure, a visual assessment of the results is provided.
- The structure-based in silico screening for similar drug-like compounds enables the detection of scaffold-hoppers with putatively similar effects.
- The possibility to find similar binding sites can be of special interest in the functional analysis of proteins.
- The search for structurally similar proteins allows the detection of similar folds with different backbone topology.
Keywords:
- structural similarity
- protein structure
- small molecule structure
- 3D structure
- protein similarity
Literature & Tutorials:
PubMed Link: Superimpose: a 3D structural superposition server
This record last updated: 07-18-2008