RosettaDock -- server for local protein-protein docking
What you can do:
Predicts the structure of protein complexes given the structures of the individual components and an approximate binding orientation.
Highlights:
- Identifies low-energy conformations of a protein-protein interaction near a given starting configuration by optimizing rigid-body orientation and side-chain conformations.
- The server requires two protein structures as inputs and a starting location for the search.
- RosettaDock generates 1000 independent structures, and the server returns pictures, coordinate files and detailed scoring information for the 10 top-scoring models.
- A plot of the total energy of each of the 1000 models created shows the presence or absence of an energetic binding funnel.
- RosettaDock has been validated on the docking benchmark set and through the Critical Assessment of PRedicted Interactions blind prediction challenge.
Keywords:
- protein-protein docking
- docking
- protein-protein interaction
Literature & Tutorials:
This record last updated: 07-23-2008