THOR -- targeted high-throughput ortholog reconstructor
What you can do:
Designed to assemble target genomic sequence orthologs in low-coverage genomes.
Highlights:
- Low-coverage genomes (LCGs) are becoming an increasingly important source of data for phylogenetic studies.
- However, assembly of these genomes is time consuming, difficult and lags behind sequence generation.
- THOR is a fast, stringent application for targeted reconstruction of sequence orthologs in unassembled LCGs.
- Using a 4x coverage set of mouse whole-genome sequence reads, THOR could partially or completely reconstruct 416/1000 human promoter ortholog regions in approximately 7.3 min/promoter.
- THOR's reconstruction rate improves markedly with both higher-coverage, and less divergent target species.
Keywords:
- ortholog
- orthologue
- phylogeny
- sequence orthologs
- Low-coverage genomes
- LCG
Literature & Tutorials:
This record last updated: 08-07-2008