TFCONES -- Transcription Factor Genes & Associated COnserved Noncoding ElementS
What you can do:
A database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements.
Highlights:
- FCONES contains all human, mouse and fugu TF-encoding genes and conserved noncoding elements (CNEs) associated with them.
- The CNEs were identified by gene-by-gene alignments of orthologous TF-encoding gene loci using MLAGAN.
- We also predicted putative transcription factor binding sites within the CNEs.
- A significant proportion of human-fugu CNEs contain experimentally defined binding sites for transcriptional activators and repressors, indicating that a majority of the CNEs may function as transcriptional regulatory elements.
- The TF-encoding genes that are involved in nervous system development are generally enriched for human-fugu CNEs.
- Users can retrieve TF-encoding genes and their associated CNEs by conducting a keyword search or by selecting a family of DNA-binding proteins.
Keywords:
- Transcription Factors
- Noncoding Elements
- Conserved Noncoding Elements
- CNE
- fugu
- TF
- Transcription Factor Binding Site
Literature & Tutorials:
This record last updated: 12-11-2008