RHYTHM -- Transmembrane Helix Orientation Predictor

URL:
http://proteinformatics.charite.de/rhythm/
What you can do:
Use to predict buried versus exposed residues of helical membrane proteins.
Highlights:
  • RHYTHM is a web server that calculates secondary and tertiary structure information.
  • The prediction applies structural information from a growing data base of precalculated packing files and evolutionary information from sequence patterns conserved in a representative dataset of membrane proteins ('Pfam-domains').
  • The program uses two types of position specific matrices to account for the different geometries of packing in channels and transporters ('channels') or other membrane proteins ('membrane-coils').
  • The output provides information on the secondary structure and topology of the protein and specifically on the contact type of each residue and its conservation.
  • This information can be downloaded as a graphical file for illustration, a text file for analysis and statistics and a PyMOL file for modeling purposes.
Keywords:
  • helix
  • transmembrane protein
  • channel protein
  • membrane coil
  • secondary protein structure
  • tertiary protein structure
Literature & Tutorials:
PubMed Link: RHYTHM--a server to predict the orientation of transmembrane helices in channels and membrane-coils
This record last updated: 08-13-2009
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