iSARST -- Integrated Structured similarity search Aided by Ramachandran Sequential Transformation
What you can do:
Perform protein structural similarity searches.
Highlights:
- iSARST is a multi-processor, batch-processing and integrated implementation of several structural comparison tools and two database searching methods: SARST for common structural homologs and CPSARST for homologs with circular permutations.
- iSARST allows users submitting multiple PDB/SCOP entry IDs or an archive file containing many structures.
- After scanning the target database using SARST/CPSARST, the ordering of hits are refined with conventional structure alignment tools such as FAST, TM-align and SAMO, which are run in a PC cluster.
- It achieves a high running speed while preserving the high precision of refinement engines.
- The final outputs include tables listing co-linear or circularly permuted homologs of the query proteins and a functional summary of the best hits.
- Superimposed structures can be examined through an interactive and informative visualization tool.
- iSARST provides batch mode structural comparison web service for both co-linear homologs and circular permutants.
- It can serve as a rapid annotation system for functionally unknown or hypothetical proteins.
Keywords:
- protein structure alignment
- structural homolog
Literature & Tutorials:
This record last updated: 08-13-2009