RosettaAntibody -- Antibody Modeling Server
What you can do:
Use to predict antibody Fv structures.
Highlights:
- The RosettaAntibody server predicts the structure of an antibody variable region given the amino-acid sequences of the respective light and heavy chains.
- The server identifies and displays the most sequence homologous template structures for the light and heavy framework regions and each of the complementarity determining region (CDR) loops.
- The most homologous templates are assembled into a side-chain optimized crude model, and the server returns a picture and coordinate file.
- For users requesting a high-resolution model, the server executes the full RosettaAntibody protocol which additionally models the hyper-variable CDR H3 loop.
- The high-resolution protocol also relieves steric clashes by optimizing the CDR backbone torsion angles and by simultaneously perturbing the relative orientation of the light and heavy chains.
- It generates 2000 independent structures, and the server returns pictures, coordinate files, and detailed scoring information for the 10 top-scoring models.
- The 10 models enable users to use rational judgment in choosing the best model or to use the set as an ensemble for further studies such as docking.
Keywords:
- antibody
- immune system
- antibody-antigen complex structure
- antibody variable region
- antibody light chain
- antibody heavy chain
- antibody structure
Literature & Tutorials:
This record last updated: 08-18-2009