ToppGenet -- Prioritization of neighboring genes in Protein-Protein Interaction Network, from ToppGene Suite

URL:

http://toppgene.cchmc.org/network_prioritization.jsp

What you can do:

Identify and prioritize the neighboring genes in a gene network.

Highlights:

ToppGenet is part of ToppGene Suite, a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome.
ToppGenet focuses on identifying and prioritizing the neighboring genes of the seeds in protein-protein interaction network based on functional similarity to the "seed" list (ToppGene) or topological features in protein-protein interaction network (ToppNet).
Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations.
The similarity scores from individual features are combined into an overall score using statistical meta-analysis.
A P-value of each annotation of a test gene is derived by random sampling of the whole genome.
The protein-protein interaction network (PPIN)-based disease candidate gene prioritization uses social and Web networks analysis algorithms (extended versions of the PageRank and HITS algorithms, and the K-Step Markov method).

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This record last updated: 09-25-2009