ComSin -- Database of complex and simple protein structures
What you can do:
Find information about the structure of proteins in their bound and unbound states.
Highlights:
- ComSin is a database of protein structures in bound (complex) and unbound (single) states to provide a researcher with exhaustive information on structures of the same or homologous proteins in bound and unbound states.
- From the complete Protein Data Bank (PDB), 24 910 pairs of protein structures in bound and unbound states were selected, and regions of intrinsic disorder were identified.
- For 2448 pairs, the proteins in bound and unbound states are identical, while 7129 pairs have sequence identity 90% or larger.
- The developed server enables one to search for proteins in bound and unbound states with several options including sequence similarity between the corresponding proteins in bound and unbound states, and validation of interaction interfaces of protein complexes.
- One can obtain necessary information for studying disorder-to-order and order-to-disorder transitions upon complex formation, and analyze structural differences between proteins in bound and unbound states.
Keywords:
- protein structure
- bound protein
- unbound protein
- complex protein structure
- single protein structure
Literature & Tutorials:
This record last updated: 02-03-2010