Negatome -- Non-interacting protein pairs database
What you can do:
Find information about proteins that do not interact with each other.
Highlights:
- The Negatome is a collection of protein and domain pairs that are unlikely to be engaged in direct physical interactions.
- It currently contains experimentally supported non-interacting protein pairs derived from two distinct sources: by manual curation of literature and by analyzing protein complexes with known 3D structure.
- More stringent lists of non-interacting pairs were derived from these two datasets by excluding interactions detected by high-throughput approaches.
- Non-interacting protein domains have been derived from the stringent manual and structural data, respectively.
- The Negatome is much less biased toward functionally dissimilar proteins than the negative data derived by randomly selecting proteins from different cellular locations.
- It can be used to evaluate protein and domain interactions from new experiments and improve the training of interaction prediction algorithms.
Keywords:
- protein-protein interaction
- non-interacting protein pairs
- Protein Data Bank
- protein interaction prediction algorithm
Literature & Tutorials:
This record last updated: 03-01-2010